Cellosaurus cell line G-OF4iPS23 (CVCL

Cross-references
Cell line name	G-OF4iPS23
Accession	CVCL_WL22
Resource Identification Initiative	To cite this cell line use: G-OF4iPS23 (RRID:CVCL_WL22)
Comments	Derived from site: In situ; Oral cavity, oral mucosa; UBERON=UBERON_0003729.
Sequence variations	Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Leu506Arg (c.1517T>G); Zygosity=Heterozygous (PubMed=28915250).
Disease	Nevoid basal cell carcinoma syndrome (NCIt: C2892) Gorlin syndrome (ORDO: Orphanet_377)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	20-25Y
Category	Induced pluripotent stem cell
Publications	PubMed=28915250; DOI=10.1371/journal.pone.0184702; PMCID=PMC5600381 Onodera S., Saito A., Hasegawa D., Morita N., Watanabe K., Nomura T., Shibahara T., Ohba S., Yamaguchi A., Azuma T. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. PLoS ONE 12:E0184702-E0184702(2017) PubMed=29088246; DOI=10.1371/journal.pone.0186879; PMCID=PMC5663396 Hasegawa D., Ochiai-Shino H., Onodera S., Nakamura T., Saito A., Onda T., Watanabe K., Nishimura K., Ohtaka M., Nakanishi M., Kosaki K., Yamaguchi A., Shibahara T., Azuma T. Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE 12:E0186879-E0186879(2017)
Encyclopedic resources	Wikidata; Q93558138
Entry history
Entry creation	24-May-2019
Last entry update	19-Dec-2024
Version number	9