Cellosaurus cell line MG63.3 (CVCL

Cellosaurus MG63.3 (CVCL_WL01)

Cross-references
Cell line name	MG63.3
Accession	CVCL_WL01
Resource Identification Initiative	To cite this cell line use: MG63.3 (RRID:CVCL_WL01)
Comments	Population: Caucasian. Characteristics: Has a high metastatic potential. Omics: H3K4me1 ChIP-seq epigenome analysis. Omics: H3K27ac ChIP-seq epigenome analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Disease	Osteosarcoma (NCIt: C9145) Osteosarcoma (ORDO: Orphanet_668)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_R705 (MG63.2)
Sex of cell	Male
Age at sampling	14Y
Category	Cancer cell line
Publications	PubMed=26320182; DOI=10.18632/oncotarget.5177; PMCID=PMC4745740 Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P.S., Khanna C. Characterization of the metastatic phenotype of a panel of established osteosarcoma cells. Oncotarget 6:29469-29481(2015) PubMed=29334376; DOI=10.1038/nm.4475; PMCID=PMC5803371 Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H.H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C. Positively selected enhancer elements endow osteosarcoma cells with metastatic competence. Nat. Med. 24:176-185(2018)
Encyclopedic resources	Wikidata; Q95989262
Gene expression databases	GEO; GSM1915000 GEO; GSM1915001 GEO; GSM1915002 GEO; GSM1915003 GEO; GSM1915030 GEO; GSM1915031 GEO; GSM1915032 GEO; GSM2635313 GEO; GSM2635314
Entry history
Entry creation	24-May-2019
Last entry update	19-Dec-2024
Version number	9