ID   MCF-7 R27
AC   CVCL_WK73
SY   R27
DR   cancercelllines; CVCL_WK73
DR   Wikidata; Q95986105
RX   PubMed=7228867;
RX   PubMed=9023415;
CC   Population: Caucasian.
CC   HLA typing: A*02:01; B*44:02; C*05:01 (PubMed=9023415).
CC   Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 8
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RX   PubMed=7228867; DOI=10.1016/S0021-9258(19)69359-2;
RA   Nawata H., Bronzert D.A., Lippman M.E.;
RT   "Isolation and characterization of a tamoxifen-resistant cell line
RT   derived from MCF-7 human breast cancer cells.";
RL   J. Biol. Chem. 256:5016-5021(1981).
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.;
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//