ID   MELN
AC   CVCL_WI91
SY   MCF-7 ERE-beta-globin Luciferase Neo
DR   cancercelllines; CVCL_WI91
DR   Wikidata; Q95988749
RX   PubMed=10492897;
RX   PubMed=11312541;
CC   Population: Caucasian.
CC   Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
CC   Characteristics: The luciferase reporter gene is under the control of an estrogen-responsive element from the beta-globin promoter.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 10-09-24; Version: 10
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RX   PubMed=10492897; DOI=10.1016/S0048-9697(99)00178-3;
RA   Balaguer P., Francois F., Comunale F., Fenet H., Boussioux A.-M.,
RA   Pons M., Nicolas J.-C., Casellas C.;
RT   "Reporter cell lines to study the estrogenic effects of
RT   xenoestrogens.";
RL   Sci. Total Environ. 233:47-56(1999).
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RX   PubMed=11312541; DOI=10.1002/bio.630;
RA   Balaguer P., Boussioux A.-M., Demirpence E., Nicolas J.-C.;
RT   "Reporter cell lines are useful tools for monitoring biological
RT   activity of nuclear receptor ligands.";
RL   Luminescence 16:153-158(2001).
//