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Cellosaurus HELN(beta) (CVCL_WI89)

[Text version]
Cell line name HELN(beta)
Synonyms HELN ERbeta; HELN-ERbeta
Accession CVCL_WI89
Resource Identification Initiative To cite this cell line use: HELN(beta) (RRID:CVCL_WI89)
Comments Population: African American.
Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
Characteristics: The luciferase reporter gene is under the control of an estrogen-responsive element from the beta-globin promoter.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3468; ESR2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WI87 (HELN)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=10492897; DOI=10.1016/S0048-9697(99)00178-3
Balaguer P., Francois F., Comunale F., Fenet H., Boussioux A.-M., Pons M., Nicolas J.-C., Casellas C.
Reporter cell lines to study the estrogenic effects of xenoestrogens.
Sci. Total Environ. 233:47-56(1999)

PubMed=11312541; DOI=10.1002/bio.630
Balaguer P., Boussioux A.-M., Demirpence E., Nicolas J.-C.
Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands.
Luminescence 16:153-158(2001)

Cross-references
Encyclopedic resources Wikidata; Q94101428
Entry history
Entry creation24-May-2019
Last entry update10-Sep-2024
Version number10