Cellosaurus cell line IR-M2 (CVCL

Cross-references
Cell line name	IR-M2
Accession	CVCL_WI72
Resource Identification Initiative	To cite this cell line use: IR-M2 (RRID:CVCL_WI72)
Comments	Population: African American. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:6091; INSR; Simple; p.Ala2Gly (c.5C>G); ClinVar=VCV000193063; Zygosity=Homozygous (PubMed=25059784).
Disease	Donohue syndrome (NCIt: C84676) Leprechaunism (ORDO: Orphanet_508)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_9X16 (GM10277)
Sex of cell	Female
Age at sampling	15Y
Category	Induced pluripotent stem cell
Publications	PubMed=25059784; DOI=10.2337/db14-0109; PMCID=PMC4238001 Iovino S., Burkart A.M., Kriauciunas K.M., Warren L., Hughes K.J., Molla M., Lee Y.-K., Patti M.-E., Kahn C.R. Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells. Diabetes 63:4130-4142(2014) PubMed=26831110; DOI=10.1073/pnas.1525665113; PMCID=PMC4763759 Iovino S., Burkart A.M., Warren L., Patti M.-E., Kahn C.R. Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 113:1889-1894(2016)
Cell line databases/resources	SKIP; SKIP000913
Encyclopedic resources	Wikidata; Q94323662
Entry history
Entry creation	24-May-2019
Last entry update	19-Dec-2024
Version number	9