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Cellosaurus IR-M1 (CVCL_WI71)

[Text version]
Cell line name IR-M1
Accession CVCL_WI71
Resource Identification Initiative To cite this cell line use: IR-M1 (RRID:CVCL_WI71)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 6091; INSR; Simple; p.Arg924Ter (c.2770C>T) (R897*); ClinVar=VCV000014686; Zygosity=Heterozygous (PubMed=25059784).
Disease Donohue syndrome (NCIt: C84676)
Leprechaunism (ORDO: Orphanet_508)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9W99 (GM05241)
Sex of cell Female
Age at sampling 1M
Category Induced pluripotent stem cell
Publications

PubMed=25059784; DOI=10.2337/db14-0109; PMCID=PMC4238001
Iovino S., Burkart A.M., Kriauciunas K., Warren L., Hughes K.J., Molla M., Lee Y.-K., Patti M.-E., Kahn C.R.
Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells.
Diabetes 63:4130-4142(2014)

PubMed=26831110; DOI=10.1073/pnas.1525665113; PMCID=PMC4763759
Iovino S., Burkart A.M., Warren L., Patti M.-E., Kahn C.R.
Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.
Proc. Natl. Acad. Sci. U.S.A. 113:1889-1894(2016)

Cross-references
Cell line databases/resources SKIP; SKIP000912
Encyclopedic resources Wikidata; Q94323659
Entry history
Entry creation24-May-2019
Last entry update29-Jun-2023
Version number9