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Cellosaurus MIA PaCa-2 GR300 (CVCL_WI24)

[Text version]
Cell line name MIA PaCa-2 GR300
Synonyms MiaPaCa-2 GR300
Accession CVCL_WI24
Resource Identification Initiative To cite this cell line use: MIA PaCa-2 GR300 (RRID:CVCL_WI24)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0428 (MIA PaCa-2)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=25485960; DOI=10.4161/15384047.2014.986967; PMCID=PMC4623403
Samulitis B.K., Pond K.W., Pond E., Cress A.E., Patel H., Wisner L., Patel C., Dorr R.T., Landowski T.H.
Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors.
Cancer Biol. Ther. 16:43-51(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WI24
Encyclopedic resources Wikidata; Q95989682
Entry history
Entry creation24-May-2019
Last entry update05-Oct-2023
Version number9