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Cellosaurus K562/DAC (CVCL_WI19)

[Text version]
Cell line name K562/DAC
Accession CVCL_WI19
Resource Identification Initiative To cite this cell line use: K562/DAC (RRID:CVCL_WI19)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50131; 5-aza-2'-deoxycytidine (Decitabine).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=30793488; DOI=10.1111/jcmm.14221; PMCID=PMC6484323
Wen X.-M., Zhang T.-J., Ma J.-C., Zhou J.-D., Xu Z.-J., Zhu X.-W., Yuan Q., Ji R.-B., Chen Q., Deng Z.-Q., Lin J., Qian J.
Establishment and molecular characterization of decitabine-resistant K562 cells.
J. Cell. Mol. Med. 23:3317-3324(2019)

Cross-references
Encyclopedic resources Wikidata; Q94335820
Entry history
Entry creation24-May-2019
Last entry update02-May-2024
Version number11