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Cellosaurus GRINCH (CVCL_WH61)

[Text version]
Cell line name GRINCH
Synonyms Glucose-Responsive INsulin-secreting C-peptide-modified Human-proinsulin
Accession CVCL_WH61
Resource Identification Initiative To cite this cell line use: GRINCH (RRID:CVCL_WH61)
Comments Characteristics: Transfected with the hPro-CpepSfGFP construct containing human insulin with a C-peptide modified with a C-terminal Superfolder GFP insert.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=FPbase; B4SOW; Superfolder GFP (Note=sfGFP, superfolding variant of GFP).
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS:0000603.
Hierarchy Parent: CVCL_0352 (INS-1)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=23223446; DOI=10.1074/jbc.M112.420018; PMCID=PMC3548498
Haataja L., Snapp E., Wright J., Liu M., Hardy A.B., Wheeler M.B., Markwardt M.L., Rizzo M., Arvan P.
Proinsulin intermolecular interactions during secretory trafficking in pancreatic beta cells.
J. Biol. Chem. 288:1896-1906(2013)

CLPUB00488
Taneera J., Haataja L., Wollheim C.B., Groop L.C.
FTO silencing inhibits insulin secretion in GRINCH cells: a new pancreatic beta cell line tool for beta cell function.
(In conference) Abstracts of EASD virtual meeting; pp.AB338-AB338; European Association for the Study of Diabetes; Dusseldorf; Germany (2016)

Cross-references
Encyclopedic resources Wikidata; Q93934841
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number6