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Cellosaurus KKP HR (CVCL_WH06)

[Text version]
Cell line name KKP HR
Accession CVCL_WH06
Resource Identification Initiative To cite this cell line use: KKP HR (RRID:CVCL_WH06)
Comments Doubling time: 27 hours (PubMed=26919099).
Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Ser903Arg (c.2709T>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1170Ala (c.3508C>G); ClinVar=VCV000134082; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WH05 (KKP)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=26919099; DOI=10.18632/oncotarget.7575; PMCID=PMC4951299
Arienti C., Zanoni M., Pignatta S., Del Rio A., Carloni S., Tebaldi M., Tedaldi G., Tesei A.
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
Oncotarget 7:18424-18439(2016)

Cross-references
Encyclopedic resources Wikidata; Q94340160
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number8