ID   AKG HR
AC   CVCL_WH03
DR   cancercelllines; CVCL_WH03
DR   Wikidata; Q93324025
RX   PubMed=26919099;
CC   Doubling time: 33 hours (PubMed=26919099).
CC   Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
CC   Sequence variation: Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Leu1061Pro (c.3182T>C); ClinVar=VCV000134079; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1170Ala (c.3508C>G); ClinVar=VCV000134082; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_WH02 ! AKG
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=26919099; DOI=10.18632/oncotarget.7575; PMCID=PMC4951299;
RA   Arienti C., Zanoni M., Pignatta S., Del Rio A., Carloni S.,
RA   Tebaldi M., Tedaldi G., Tesei A.;
RT   "Preclinical evidence of multiple mechanisms underlying trastuzumab
RT   resistance in gastric cancer.";
RL   Oncotarget 7:18424-18439(2016).
//