Cellosaurus logo
expasy logo

Cellosaurus HD10.6 (CVCL_WG82)

[Text version]
Cell line name HD10.6
Accession CVCL_WG82
Resource Identification Initiative To cite this cell line use: HD10.6 (RRID:CVCL_WG82)
Comments Characteristics: Immortalized dorsal root ganglion (DRG) cell line that in the presence of doxycycline can differentiate into sensory neurons with nociceptive features (PubMed=10377351).
Virology: Susceptible to infection by herpes simplex virus 1 (HHV-1). A quiescent state resembling latency can be established in the HSV-1 infection in the presence of acyclovir (PubMed=28404842).
Doubling time: 1.2 days (PubMed=10377351).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: v-Myc (Note=Tetracycline-regulated).
Miscellaneous: STR profile from personal communication of Triezenberg, Steven J.
Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
Cell type: Neuron; CL=CL_0000540.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling <12FW
Category Transformed cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811,12
D7S82010,13
D13S31711
D16S5399,10
TH018,9.3
TPOX10,12
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=10377351; DOI=10.1523/JNEUROSCI.19-13-05420.1999; PMCID=PMC6782307
Raymon H.K., Thode S., Zhou J.-Y., Friedman G.C., Pardinas J.R., Barrere C., Johnson R.M., Sah D.W.Y.
Immortalized human dorsal root ganglion cells differentiate into neurons with nociceptive properties.
J. Neurosci. 19:5420-5428(1999)

CLPUB00486
Thellman N.M.
A human neuronal model for herpes simplex virus latency and reactivation.
Thesis PhD (2017); Van Andel Research Institute; Grand Rapids; USA

PubMed=28404842; DOI=10.1128/JVI.00080-17; PMCID=PMC5446634
Thellman N.M., Botting C., Madaj Z., Triezenberg S.J.
An immortalized human dorsal root ganglion cell line provides a novel context to study herpes simplex virus 1 latency and reactivation.
J. Virol. 91:e00080.17.1-e00080.17.18(2017)

PubMed=32636736; DOI=10.3389/fncel.2020.00184; PMCID=PMC7319018
Haberberger R.V., Barry C.M., Matusica D.
Immortalized dorsal root ganglion neuron cell lines.
Front. Cell. Neurosci. 14:184.1-184.21(2020)

PubMed=35890047; DOI=10.3390/pathogens11070803; PMCID=PMC9317301
Chen Y.-C., Li H.-D., Martin-Caraballo M., Hsia S.-C.V.
Establishing a herpesvirus quiescent infection in differentiated human dorsal root ganglion neuronal cell line mediated by micro-RNA overexpression.
Pathogens 11:803.1-803.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q93986083
Entry history
Entry creation24-May-2019
Last entry update10-Sep-2024
Version number9