Cell line name |
SW1573/3R80 |
Synonyms |
SW-1573/3R80; 3R80 |
Accession |
CVCL_WG72 |
Resource Identification Initiative |
To cite this cell line use: SW1573/3R80 (RRID:CVCL_WG72) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin). Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=1974823 Baas F., Jongsma A.P.M., Broxterman H.J., Arceci R.J., Housman D.E., Scheffer G.L., Riethorst A., van Groenigen M., Nieuwint A.W.M., Joenje H. Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res. 50:5392-5398(1990) PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895 Eijdems E.W.H.M., Borst P., Jongsma A.P.M., de Jong S., de Vries E.G.E., van Groenigen M., Versantvoort C.H.M., Nieuwint A.W.M., Baas F. Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype. Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992) PubMed=1353703 Nieuwint A.W.M., Baas F., Wiegant J., Joenje H. Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines. Cancer Res. 52:4361-4371(1992) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_WG72
|
Encyclopedic resources |
Wikidata; Q98132925
|
Entry history |
Entry creation | 24-May-2019 |
Last entry update | 19-Dec-2024 |
Version number | 9 |
---|