Cellosaurus cell line BM 2.2.1 (CVCL

Cellosaurus BM 2.2.1 (CVCL_W999)

Cross-references
Cell line name	BM 2.2.1
Synonyms	BM2.2.1; ASL 5; ASL-w17
Accession	CVCL_W999
Resource Identification Initiative	To cite this cell line use: BM 2.2.1 (RRID:CVCL_W999)
Comments	Population: Caucasian. Doubling time: 52.8-55.2 hours (Note=At 23th passage) (PubMed=10952247). Karyotypic information: Has lost chromosome Y. Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Myofibroblast; CL=CL_0000186.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Leu (c.536A>T); ClinVar=VCV000376608; Zygosity=Homozygous (PubMed=7658501; PubMed=10022320; PubMed=10952247).
Disease	Liver angiosarcoma (NCIt: C4438) Angiosarcoma (ORDO: Orphanet_263413)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	60Y
Category	Cancer cell line
Publications	PubMed=7658501; DOI=10.1093/jnci/87.18.1400 Trivers G.E., Cawley H.L., DeBenedetti V.M.G., Hollstein M., Marion M.-J., Bennett W.P., Hoover M.L., Prives C.L., Tamburro C.C., Harris C.C. Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride. J. Natl. Cancer Inst. 87:1400-1407(1995) PubMed=10022320; DOI=10.1016/S0378-4274(98)00255-0 Marion M.-J. Critical genes as early warning signs: example of vinyl chloride. Toxicol. Lett. 102:603-607(1998) PubMed=10952247; DOI=10.1016/S0168-8278(00)80370-0 Boivin-Angele S., Pedron S., Bertrand S., Desmouliere A., Martel-Planche G., Lefrancois L., Bancel B., Trepo C., Marion M.-J. Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. J. Hepatol. 33:290-300(2000)
Cell line databases/resources	cancercelllines; CVCL_W999
Encyclopedic resources	Wikidata; Q54797439
Polymorphism and mutation databases	IARC_TP53; 4803 IARC_TP53; 9738
Entry history
Entry creation	17-Jul-2014
Last entry update	19-Dec-2024
Version number	14