Cell line name |
SH-IN |
Accession |
CVCL_W974 |
Resource Identification Initiative |
To cite this cell line use: SH-IN (RRID:CVCL_W974) |
Comments |
Population: Caucasian. Characteristics: Intermediate type (I-type) (PubMed=15720811). Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371. |
Sequence variations |
- Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Neuroblastoma (NCIt: C3270) Neuroblastoma (ORDO: Orphanet_635) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0531 (SK-N-SH) |
Sex of cell |
Female |
Age at sampling |
4Y |
Category |
Cancer cell line |
Publications | PubMed=6137586; DOI=10.1093/jnci/71.4.741 Ross R.A., Spengler B.A., Biedler J.L. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J. Natl. Cancer Inst. 71:741-747(1983) PubMed=2535691 Ciccarone V.C., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A. Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res. 49:219-225(1989) PubMed=1354203; DOI=10.1002/ijc.2910520116 Gross N., Favre S., Beck D., Meyer M. Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants. Int. J. Cancer 52:85-91(1992) PubMed=15720811; DOI=10.1593/neo.04310; PMCID=PMC1531688 Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 6:838-845(2004) PubMed=26342562; DOI=10.1016/j.scr.2015.08.008; PMCID=PMC4601571 Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V. A distinct gene expression signature characterizes human neuroblastoma cancer stem cells. Stem Cell Res. 15:419-426(2015) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_W974
|
Encyclopedic resources |
Wikidata; Q54953220
|
Entry history |
Entry creation | 17-Jul-2014 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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