Cell line name |
MCF-7/6 |
Synonyms |
MCF-7-6 |
Accession |
CVCL_W972 |
Resource Identification Initiative |
To cite this cell line use: MCF-7/6 (RRID:CVCL_W972) |
Comments |
Population: Caucasian. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) |
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=1648947; DOI=10.1038/bjc.1991.191; PMCID=PMC1972531 Bracke M.E., Van Larebeke N.A.F., Vyncke B.M., Mareel M.M. Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro. Br. J. Cancer 63:867-872(1991) PubMed=8528519; DOI=10.1007/BF02634317 Deman J.J., Van Larebeke N.A.F., Bruyneel E.A., Bracke M.E., Vermeulen S.J., Vennekens K.M., Mareel M.M. Removal of sialic acid from the surface of human MCF-7 mammary cancer cells abolishes E-cadherin-dependent cell-cell adhesion in an aggregation assay. In Vitro Cell. Dev. Biol. Anim. 31:633-639(1995) PubMed=22161839; DOI=10.1387/ijdb.113336ld Derycke L., Stove C., Vercoutter-Edouart A.-S., De Wever O., Dolle L., Colpaert N., Depypere H., Michalski J.-C., Bracke M.E. The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells. Int. J. Dev. Biol. 55:835-840(2011) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_W972
|
Encyclopedic resources |
Wikidata; Q54904350
|
Polymorphism and mutation databases |
Cosmic; 2036670
|
Entry history |
Entry creation | 17-Jul-2014 |
Last entry update | 19-Dec-2024 |
Version number | 16 |
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