ID   MCF-7/AZ
AC   CVCL_W971
SY   MCF-7AZ
DR   cancercelllines; CVCL_W971
DR   Cosmic; 2036668
DR   Wikidata; Q54904357
RX   PubMed=1648947;
RX   PubMed=8528519;
RX   PubMed=22161839;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 05-10-23; Version: 15
//
RX   PubMed=1648947; DOI=10.1038/bjc.1991.191; PMCID=PMC1972531;
RA   Bracke M.E., Van Larebeke N.A.F., Vyncke B.M., Mareel M.M.;
RT   "Retinoic acid modulates both invasion and plasma membrane ruffling of
RT   MCF-7 human mammary carcinoma cells in vitro.";
RL   Br. J. Cancer 63:867-872(1991).
//
RX   PubMed=8528519; DOI=10.1007/BF02634317;
RA   Deman J.J., Van Larebeke N.A.F., Bruyneel E.A., Bracke M.E.,
RA   Vermeulen S.J., Vennekens K.M., Mareel M.M.;
RT   "Removal of sialic acid from the surface of human MCF-7 mammary cancer
RT   cells abolishes E-cadherin-dependent cell-cell adhesion in an
RT   aggregation assay.";
RL   In Vitro Cell. Dev. Biol. Anim. 31:633-639(1995).
//
RX   PubMed=22161839; DOI=10.1387/ijdb.113336ld;
RA   Derycke L., Stove C., Vercoutter-Edouart A.-S., De Wever O., Dolle L.,
RA   Colpaert N., Depypere H., Michalski J.-C., Bracke M.E.;
RT   "The role of non-muscle myosin IIA in aggregation and invasion of
RT   human MCF-7 breast cancer cells.";
RL   Int. J. Dev. Biol. 55:835-840(2011).
//