ID   THJ-11T
AC   CVCL_W919
SY   THJ11T
DR   cancercelllines; CVCL_W919
DR   Cosmic; 2054093
DR   Wikidata; Q54972300
RX   PubMed=20810568;
RX   PubMed=23724124;
RX   PubMed=23833040;
CC   Doubling time: 30 hours (PubMed=20810568).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=20810568; PubMed=23833040).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040).
CC   Miscellaneous: STR profile and age of donor from personal communication of Marlow, Laura A.
CC   Caution: Cell line wrongly indicated as being female in figure 2A of PubMed=20810568.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,13
ST   D16S539: 12,13
ST   D18S51: 12,14
ST   D3S1358: 14,17
ST   D5S818: 13
ST   D7S820: 9
ST   D8S1179: 13
ST   FGA: 21,24
ST   TH01: 5,6
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 19-12-24; Version: 18
//
RX   PubMed=20810568; DOI=10.1210/jc.2010-1421; PMCID=PMC2999968;
RA   Marlow L.A., D'Innocenzi J., Zhang Y.-L., Rohl S.D., Cooper S.J.,
RA   Sebo T.J., Grant C., McIver B., Kasperbauer J.L., Wadsworth J.T.,
RA   Casler J.D., Kennedy P.W., Highsmith W.E. Jr., Clark O., Milosevic D.,
RA   Netzel B.C., Cradic K.W., Arora S., Beaudry C., Grebe S.K.G.,
RA   Silverberg M.L., Azorsa D.O., Smallridge R.C., Copland J.A. 3rd;
RT   "Detailed molecular fingerprinting of four new anaplastic thyroid
RT   carcinoma cell lines and their use for verification of RhoB as a
RT   molecular therapeutic target.";
RL   J. Clin. Endocrinol. Metab. 95:5338-5347(2010).
//
RX   PubMed=23724124; DOI=10.1371/journal.pone.0065095; PMCID=PMC3665717;
RA   Li W., Reeb A.N., Sewell W.A., Elhomsy G., Lin R.-Y.;
RT   "Phenotypic characterization of metastatic anaplastic thyroid cancer
RT   stem cells.";
RL   PLoS ONE 8:E65095-E65095(2013).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M.,
RA   Ibrahimpasic T., Ghossein R.A., Fagin J.A.;
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//