ID   BRG-M
AC   CVCL_W882
SY   BRG M; BRG IgM; BRG-IgM; BRG-P.1
DR   cancercelllines; CVCL_W882
DR   Cosmic; 1515196
DR   IARC_TP53; 6585
DR   Wikidata; Q54798229
RX   PubMed=8207254;
RX   PubMed=8695808;
RX   PubMed=9399658;
RX   PubMed=10702812;
CC   Population: Caucasian.
CC   Characteristics: IgM producing subclone of BRG-P.
CC   Virology: EBV-negative.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg158His (c.473G>A); ClinVar=VCV000141963; Zygosity=Heterozygous (PubMed=9399658).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286Gly (c.857_858AA>GT); Zygosity=Heterozygous (PubMed=9399658).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C2912; Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_W880 ! BRG-P
SX   Female
AG   30Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 19-12-24; Version: 14
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RX   PubMed=8207254; DOI=10.4049/jimmunol.153.1.45;
RA   Jain R., Roncella S., Hashimoto S., Carbone A., Francia di Celle P.,
RA   Foa R., Ferrarini M., Chiorazzi N.;
RT   "A potential role for antigen selection in the clonal evolution of
RT   Burkitt's lymphoma.";
RL   J. Immunol. 153:45-52(1994).
//
RX   PubMed=8695808; DOI=10.1182/blood.V88.2.599.bloodjournal882599;
RA   Roncella S., Cutrona G., Favre A., Ulivi M., Fais F., Signorini A.,
RA   Grossi C.E., Chiorazzi N., Ferrarini M.;
RT   "Apoptosis of Burkitt's lymphoma cells induced by specific interaction
RT   of surface IgM with a self-antigen: implications for lymphomagenesis
RT   in acquired immunodeficiency syndrome.";
RL   Blood 88:599-608(1996).
//
RX   PubMed=9399658; DOI=10.1002/(SICI)1097-0215(19971210)73:6<816::AID-IJC8>3.0.CO;2-5;
RA   Campomenosi P., Fronza G., Ottaggio L., Roncella S., Inga A.,
RA   Bogliolo M., Monti P., Assereto P., Moro F., Cutrona G., Bozzo S.,
RA   Chiorazzi N., Abbondandolo A., Ferrarini M.;
RT   "Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS
RT   patient with monoclonal c-myc and VDJ rearrangements.";
RL   Int. J. Cancer 73:816-821(1997).
//
RX   PubMed=10702812;
RA   Zunino A., Viaggi S., Ottaggio L., Fronza G., Schenone A.,
RA   Roncella S., Abbondandolo A.;
RT   "Chromosomal aberrations evaluated by CGH, FISH and GTG-banding in a
RT   case of AIDS-related Burkitt's lymphoma.";
RL   Haematologica 85:250-255(2000).
//