ID   WMM1175
AC   CVCL_W753
SY   WMM 1175
DR   cancercelllines; CVCL_W753
DR   Cosmic; 1102380
DR   Wikidata; Q54994350
RX   PubMed=10338330;
RX   PubMed=11595726;
RX   PubMed=15945100;
RX   PubMed=23455323;
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=15945100).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Arg (c.37G>C); ClinVar=VCV000013899; Zygosity=Unspecified (PubMed=23455323).
CC   Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 19-12-24; Version: 11
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RX   PubMed=10338330; DOI=10.1097/00008390-199902000-00003;
RA   Rizos H., Darmanian A.P., Indsto J.O., Shannon J.A., Kefford R.F.,
RA   Mann G.J.;
RT   "Multiple abnormalities of the p16INK4a-pRb regulatory pathway in
RT   cultured melanoma cells.";
RL   Melanoma Res. 9:10-19(1999).
//
RX   PubMed=11595726;
RA   Becker T.M., Rizos H., Kefford R.F., Mann G.J.;
RT   "Functional impairment of melanoma-associated p16(INK4a) mutants in
RT   melanoma cells despite retention of cyclin-dependent kinase 4
RT   binding.";
RL   Clin. Cancer Res. 7:3282-3288(2001).
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RX   PubMed=15945100; DOI=10.1002/ijc.21265;
RA   Becker T.M., Ayub A.L., Kefford R.F., Mann G.J., Rizos H.;
RT   "The melanoma-associated 24 base pair duplication in p16INK4a is
RT   functionally impaired.";
RL   Int. J. Cancer 117:569-573(2005).
//
RX   PubMed=23455323; DOI=10.1038/onc.2013.45;
RA   Becker T.M., Boyd S.C., Mijatov B., Gowrishankar K., Snoyman S.,
RA   Pupo G.M., Scolyer R.A., Mann G.J., Kefford R.F., Zhang X.-D.,
RA   Rizos H.;
RT   "Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3
RT   transcription factor.";
RL   Oncogene 33:1158-1166(2014).
//