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Cellosaurus HUES 71 (CVCL_W717)

[Text version]
Cell line name HUES 71
Synonyms HUES71
Accession CVCL_W717
Resource Identification Initiative To cite this cell line use: HUES 71 (RRID:CVCL_W717)
Comments From: Harvard University; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0281.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources NIHhESC; NIHhESC-14-0281
Encyclopedic resources Wikidata; Q54896814
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number14