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Cellosaurus MCF-7/182R-6 (CVCL_W536)

[Text version]
Cell line name MCF-7/182R-6
Synonyms MCF-7/182(R)-6; MCF7/182R-6; 182R-6
Accession CVCL_W536
Resource Identification Initiative To cite this cell line use: MCF-7/182R-6 (RRID:CVCL_W536)
Comments Population: Caucasian.
Doubling time: 24 hours (Note=In estradiol-deprived medium) (PubMed=10027303).
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ECACC=16022506

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81811,12
D7S8209
D8S117910,14
D13S31711
D16S53911,12
D18S5114
D21S1130
FGA23,25
Penta D12
Penta E7,12
TH016
TPOX9,12
vWA14,15

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Publications

PubMed=7759159; DOI=10.1002/ijc.2910610417
Lykkesfeldt A.E., Larsen S.S., Briand P.
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment.
Int. J. Cancer 61:529-534(1995)

PubMed=10027303; DOI=10.1038/sj.bjc.6690061; PMCID=PMC2362436
Jensen B.L., Skouv J., Lundholt B.K., Lykkesfeldt A.E.
Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6.
Br. J. Cancer 79:386-392(1999)

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.-V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections (Providers) CancerTools; 152105
ECACC; 16022506 - Discontinued
Ximbio; 152105
Cell line databases/resources cancercelllines; CVCL_W536
Encyclopedic resources Wikidata; Q54904343
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number24