Cell line name |
Ishikawa 3-H-4 |
Accession |
CVCL_W435 |
Resource Identification Initiative |
To cite this cell line use: Ishikawa 3-H-4 (RRID:CVCL_W435) |
Comments |
Population: Japanese. Doubling time: 31.6 hours (PubMed=9183638). Derived from site: In situ; Endometrium; UBERON=UBERON_0001295. |
Sequence variations |
- Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Endometrial adenocarcinoma (NCIt: C7359) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_2529 (Ishikawa) |
Sex of cell |
Female |
Age at sampling |
39Y |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=22710073
Markers:Amelogenin | X |
CSF1PO | 11,12 |
D2S1338 | 19,20 |
D3S1358 | 16,17 |
D5S818 | 10,11 |
D7S820 | 9,10 |
D8S1179 | 12,16 |
D13S317 | 9,12 |
D16S539 | 9 |
D18S51 | 13,21,22 |
D19S433 | 12.2,14 |
D21S11 | 28 |
FGA | 21,22 |
TH01 | 9,10 |
TPOX | 8 |
vWA | 14,17 |
Run an STR similarity search on this cell line |
Publications | PubMed=9183638 Nishida M., Kasahara K., Oki A., Satoh T., Arai Y., Kubo T. Establishment of eighteen clones of Ishikawa cells. Hum. Cell 9:109-116(1996) DOI=10.1007/978-4-431-53981-0_2 Nishida M. Ishikawa cells: opening of in vitro hormone research on endometrial carcinoma. (In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.35-58; Springer; Tokyo; Japan (2003) PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677 Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol. Oncol. 127:241-248(2012) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_W435
|
Encyclopedic resources |
Wikidata; Q54898300
|
Entry history |
Entry creation | 16-Apr-2014 |
Last entry update | 05-Oct-2023 |
Version number | 13 |
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