ID   TWNT-4
AC   CVCL_W296
SY   TWNT4
DR   Wikidata; Q54973429
RX   PubMed=12953924;
CC   Population: Japanese.
CC   Characteristics: Because it has been transduced by a construct containing LoxP sites, transfection with the Cre recombinase eliminates the TERT gene thus reverting the cells to a non-immortal phenotype.
CC   Characteristics: Transduced with a retroviral vector SSR#197 (MoMLV/LTR-LoxP-hTERT-IRES-EGFP-LoxP-MoMLV/LTR) expressing hTERT and eGFP flanked by a pair of loxP sites.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Hepatic stellate cell; CL=CL_0000632.
DI   NCIt; C3800; Epithelioid hemangioendothelioma
DI   ORDO; Orphanet_157791; Epithelioid hemangioendothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0390 ! LI90
SX   Female
AG   55Y
CA   Telomerase immortalized cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 14
//
RX   PubMed=12953924; DOI=10.3727/000000003108747064;
RA   Shibata N., Watanabe T., Okitsu T., Sakaguchi M., Takesue M.,
RA   Kunieda T., Omoto K., Yamamoto S., Tanaka N., Kobayashi N.;
RT   "Establishment of an immortalized human hepatic stellate cell line to
RT   develop antifibrotic therapies.";
RL   Cell Transplant. 12:499-507(2003).
//