Cellosaurus logo
expasy logo

Cellosaurus KM12-L4A (CVCL_W220)

[Text version]
Cell line name KM12-L4A
Synonyms Km 12 L4A; KM12L4-A; KM12L4A; KM12L4a
Accession CVCL_W220
Resource Identification Initiative To cite this cell line use: KM12-L4A (RRID:CVCL_W220)
Comments Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12496.
Registration: Chiron Master Culture Collection; CMCC 11606 (CMCC #11606).
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Gene fusion; HGNC; HGNC:8031; NTRK1 + HGNC; HGNC:12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5946 (KM12-L4)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988)

PubMed=15170669; DOI=10.1002/ijc.20195
Camps J., Morales C., Prat E., Ribas M., Capella G., Egozcue J., Peinado M.A., Miro R.
Genetic evolution in colon cancer KM12 cells and metastatic derivates.
Int. J. Cancer 110:869-874(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W220
Encyclopedic resources Wikidata; Q54900058
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number18