ID   LK1 [Human ovarian carcinoma]
AC   CVCL_W131
SY   LK-1
DR   cancercelllines; CVCL_W131
DR   Cosmic; 724832
DR   Cosmic; 1609534
DR   GEO; GSM313698
DR   Progenetix; CVCL_W131
DR   Wikidata; Q54902669
RX   PubMed=1892748;
RX   PubMed=12068308;
RX   PubMed=15677628;
CC   Microsatellite instability: Stable (MSS) (PubMed=15677628).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=12068308).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4908; Ovarian carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 14
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RX   PubMed=1892748; DOI=10.1038/bjc.1991.279; PMCID=PMC1977519;
RA   Mistry P., Kelland L.R., Abel G., Sidhar S., Harrap K.R.;
RT   "The relationships between glutathione, glutathione-S-transferase and
RT   cytotoxicity of platinum drugs and melphalan in eight human ovarian
RT   carcinoma cell lines.";
RL   Br. J. Cancer 64:215-220(1991).
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RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C.,
RA   Edwards P.A.W., Caldas C.;
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//