• Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=8839862; PubMed=9192750; PubMed=12353268).
  
• Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:9864; RARA; Simple; p.Leu398Pro (c.1193T>C); Zygosity=Unspecified; Note=Equivalent to p.Leu890Pro in the PML-RARA fusion protein (PubMed=9192750).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
  

PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671
Rosenauer A., Raelson J.V., Nervi C., Eydoux P., DeBlasio A., Miller W.H. Jr.
Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines.
Blood 88:2671-2682(1996)

PubMed=9192750; DOI=10.1182/blood.V89.12.4282
Shao W.-L., Benedetti L., Lamph W.W., Nervi C., Miller W.H. Jr.
A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
Blood 89:4282-4289(1997)

PubMed=12353268; DOI=10.1002/gcc.10117
Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M.
Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
Genes Chromosomes Cancer 35:261-270(2002)