Cellosaurus cell line Hermes 4C (CVCL

Cellosaurus Hermes 4C (CVCL_VS21)

Cross-references
Cell line name	Hermes 4C
Synonyms	Hermes4C; Human extended-replication melanocytes-4C
Accession	CVCL_VS21
Resource Identification Initiative	To cite this cell line use: Hermes 4C (RRID:CVCL_VS21)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471. Cell type: Melanocyte of foreskin; CL=CL_2000045.
Sequence variations	Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Arg160Trp (c.478C>T); ClinVar=VCV000014310; Zygosity=Heterozygous (PubMed=16880792). Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Asp294His (c.880G>C); ClinVar=VCV000014307; Zygosity=Heterozygous (PubMed=16880792).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_VS18 (830-c)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=16880792; DOI=10.1038/sj.bjc.6603283; PMCID=PMC2360676 Gray-Schopfer V.C., Cheong S.-C., Chong H., Chow J., Moss T., Abdel-Malek Z.A., Marais R., Wynford-Thomas D., Bennett D.C. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br. J. Cancer 95:496-505(2006)
Encyclopedic resources	Wikidata; Q94104151
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	13