ID   Hermes 4A
AC   CVCL_VS19
SY   Hermes4A; Human extended-replication melanocytes-4A
DR   Wikidata; Q94104138
RX   PubMed=16880792;
CC   Sequence variation: Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Arg160Trp (c.478C>T); ClinVar=VCV000014310; Zygosity=Heterozygous (PubMed=16880792).
CC   Sequence variation: Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Asp294His (c.880G>C); ClinVar=VCV000014307; Zygosity=Heterozygous (PubMed=16880792).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Melanocyte of foreskin; CL=CL_2000045.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VS18 ! 830-c
SX   Male
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 10
//
RX   PubMed=16880792; DOI=10.1038/sj.bjc.6603283; PMCID=PMC2360676;
RA   Gray-Schopfer V.C., Cheong S.-C., Chong H., Chow J., Moss T.,
RA   Abdel-Malek Z.A., Marais R., Wynford-Thomas D., Bennett D.C.;
RT   "Cellular senescence in naevi and immortalisation in melanoma: a role
RT   for p16?";
RL   Br. J. Cancer 95:496-505(2006).
//