ID   Q34
AC   CVCL_VS16
DR   Wikidata; Q98128734
RX   PubMed=12417717;
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Met53Thr (c.158T>C); ClinVar=VCV001480737; Zygosity=Heterozygous (PubMed=12417717).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp108Asn (c.322G>A) (p.Arg122Gln, c.365G>A); ClinVar=VCV000216275; Zygosity=Heterozygous (PubMed=12417717).
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_VS15 ! Hmel-p16-2
SX   Female
AG   28Y
CA   Finite cell line
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 9
//
RX   PubMed=12417717; DOI=10.1128/mcb.22.23.8135-8143.2002; PMCID=PMC134058;
RA   Huot T.J., Rowe J., Harland M., Drayton S., Brookes S., Gooptu C.,
RA   Purkis P., Fried M., Bataille V., Hara E., Newton-Bishop J.A.,
RA   Peters G.;
RT   "Biallelic mutations in p16(INK4a) confer resistance to Ras- and
RT   Ets-induced senescence in human diploid fibroblasts.";
RL   Mol. Cell. Biol. 22:8135-8143(2002).
//