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Cellosaurus CV-hIPS-B-control APP edition clone B10 (CVCL_VR50)

[Text version]
Cell line name CV-hIPS-B-control APP edition clone B10
Synonyms GM25430-control APP edition clone B10; B10
Accession CVCL_VR50
Resource Identification Initiative To cite this cell line use: CV-hIPS-B-control APP edition clone B10 (RRID:CVCL_VR50)
Comments Population: Caucasian.
Characteristics: Control cell line for the APP-edited cell lines derived from CV-hIPS-B. Have been transfected with CAS9, guide RNA and APP repair oligo but have not been edited.
Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1N86 (CV-hIPS-B)
Sex of cell Male
Age at sampling 62Y
Category Induced pluripotent stem cell
Publications

PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424
van der Kant R., Langness V.F., Herrera C.M., Williams D.A., Fong L.K., Leestemaker Y., Steenvoorden E., Rynearson K.D., Brouwers J.F., Helms J.B., Ovaa H., Giera M., Wagner S.L., Bang A.G., Goldstein L.S.B.
Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons.
Cell Stem Cell 24:363-375.e9(2019)

Cross-references
Encyclopedic resources Wikidata; Q93460587
Entry history
Entry creation13-Nov-2018
Last entry update30-Jan-2024
Version number8