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Cellosaurus 786-TGL (CVCL_VR34)

[Text version]
Cell line name 786-TGL
Synonyms 786-HSV1-TK/GFP/Fluc
Accession CVCL_VR34
Resource Identification Initiative To cite this cell line use: 786-TGL (RRID:CVCL_VR34)
Comments Population: Caucasian.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,18
D3S135816
D5S8189
D7S82011,12
D8S117913
D13S3178
D16S53912
D18S5113,14
D19S43314,15
D21S1129,30
FGA24
TH016,9.3
TPOX8,11
vWA15,17

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Cross-references
Cell line databases/resources cancercelllines; CVCL_VR34
Encyclopedic resources Wikidata; Q93309884
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number13