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Cellosaurus 786-M2A (CVCL_VR32)

[Text version]
Cell line name 786-M2A
Accession CVCL_VR32
Resource Identification Initiative To cite this cell line use: 786-M2A (RRID:CVCL_VR32)
Comments Population: Caucasian.
Characteristics: Established from lung metastatis in NOD/SCID mice which were intravenous inoculated with the parental cell line.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR30 (786-M1A)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=23223005; DOI=10.1038/nm.3029; PMCID=PMC3540187
Vanharanta S., Shu W.-P., Brenet F., Hakimi A.A., Heguy A., Viale A.J., Reuter V.E., Hsieh J.J.-D., Scandura J.M., Massague J.
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Nat. Med. 19:50-56(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR32
Encyclopedic resources Wikidata; Q93309880
Gene expression databases GEO; GSM800330
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number11