ID   H2087-LCC1-1
AC   CVCL_VR28
SY   H2087-LCC1; H2087 LCC1; H2087-Latency Competent Cancer 1
DR   cancercelllines; CVCL_VR28
DR   GEO; GSM1875323
DR   GEO; GSM1875332
DR   Wikidata; Q93936095
RX   PubMed=27015306;
CC   Population: Caucasian.
CC   Characteristics: After 3 months was recovered from the lung of healthy FOXN1nu mice that had been intracardially injected with the parent cell line.
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Glu848Gln (c.2542G>C); ClinVar=VCV001686474; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Leu597Val (c.1789C>G); ClinVar=VCV000013969; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7553; MYC; Simple; p.Glu54Lys (c.160G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 14
ST   D21S11: 30,32.2
ST   D2S1338: 20
ST   D3S1358: 15,17
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 10
ST   FGA: 20
ST   TH01: 7,9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VR27 ! H2087-TGL
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 10-09-24; Version: 9
//
RX   PubMed=27015306; DOI=10.1016/j.cell.2016.02.025; PMCID=PMC4808520;
RA   Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L.,
RA   de Stanchina E., Massague J.;
RT   "Metastatic latency and immune evasion through autocrine inhibition of
RT   WNT.";
RL   Cell 165:45-60(2016).
//