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Cellosaurus H2087-TGL (CVCL_VR27)

[Text version]
Cell line name H2087-TGL
Synonyms H2087-HSV1-TK/GFP/Fluc
Accession CVCL_VR27
Resource Identification Initiative To cite this cell line use: H2087-TGL (RRID:CVCL_VR27)
Comments Population: Caucasian.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL) and with bsr; parent cell line for the H2087-LCC1 and H2087-LCC2.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Caution: In PubMed=27015306 and the associated GEO data sets H2087-TGL is termed H2087 Parental.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Glu848Gln (c.2542G>C); ClinVar=VCV001686474; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Leu597Val (c.1789C>G); ClinVar=VCV000013969; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7553; MYC; Simple; p.Glu54Lys (c.160G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1524 (NCI-H2087)
Children:
CVCL_VR28 (H2087-LCC1-1)CVCL_VR29 (H2087-LCC1-2)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO12
D2S133820
D3S135815,17
D5S81811
D7S8208,10
D8S117910
D13S31712
D16S5399,11
D18S5114
D19S43314
D21S1130,32.2
FGA20
TH017,9
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=27015306; DOI=10.1016/j.cell.2016.02.025; PMCID=PMC4808520
Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L., de Stanchina E., Massague J.
Metastatic latency and immune evasion through autocrine inhibition of WNT.
Cell 165:45-60(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR27
Encyclopedic resources Wikidata; Q93936103
Gene expression databases GEO; GSM1875321
GEO; GSM1875322
GEO; GSM1875329
GEO; GSM1875330
GEO; GSM1875331
GEO; GSM2066429
GEO; GSM2066433
GEO; GSM2066437
Entry history
Entry creation13-Nov-2018
Last entry update10-Sep-2024
Version number10