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Cellosaurus BLaER1 (CVCL_VQ57)

[Text version]
Cell line name BLaER1
Synonyms B cell Leukemia C/EBPalphaER clone 1
Accession CVCL_VQ57
Resource Identification Initiative To cite this cell line use: BLaER1 (RRID:CVCL_VQ57)
Comments Population: Caucasian.
Characteristics: Can efficiently be convert into cells exhibiting increased adherent, phagocytic and quiescent properties with a transcriptome resembling normal macrophages.
Characteristics: Transduced with the retrovirus vector C/EBPaER-GFP which consist of CEBPA fused with the estrogen receptor hormone binding domain and GFP.
Genetic integration: Method=Transduction; Gene=HGNC; 1833; CEBPA.
Genetic integration: Method=Transduction; Gene=HGNC; 3467; ESR1 (Note=Ligand-binding domain).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Caution: Was originally (PubMed=23545498) described as originating from the Seraphina cell line (Cellosaurus=CVCL_M646) but was later (PubMed=28494875) shown to derive from RCH-ACV.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 8632; PBX1 + HGNC; 11633; TCF3; Name(s)=TCF3-PBX1; E2A-PBX1 (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1851 (RCH-ACV)
Sex of cell Female
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC165

Markers:
AmelogeninX
CSF1PO10,11
D3S135815
D5S81811,12
D7S82010,11
D8S117913,15
D13S3179,14
D16S53911
D18S5113,16
D21S1129,31.2
FGA23,26
Penta D8.4,10
Penta E7,11
TH016,8
TPOX8,11
vWA16,17

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Publications

PubMed=23545498; DOI=10.1016/j.celrep.2013.03.003
Rapino F., Robles E.F., Richter-Larrea J.A., Kallin E.M., Martinez-Climent J.A., Graf T.
C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity.
Cell Rep. 3:1153-1163(2013)

PubMed=28494875; DOI=10.1016/j.celrep.2017.04.072
Rapino F., Robles E.F., Richter-Larrea J.A., Kallin E.M., Martinez-Climent J.A., Graf T.
Erratum: C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity.
Cell Rep. 19:1281-1281(2017)

Cross-references
Cell line collections (Providers) Millipore; SCC165
Encyclopedic resources Wikidata; Q93427919
Experimental variables resources EFO; EFO_0030018
Entry history
Entry creation13-Nov-2018
Last entry update10-Sep-2024
Version number13