Cellosaurus BLaER1 (CVCL_VQ57)
Cell line name | BLaER1 | ||||||||||||||||||||||||||||||||
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Synonyms | B cell Leukemia C/EBPalphaER clone 1 | ||||||||||||||||||||||||||||||||
Accession | CVCL_VQ57 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: BLaER1 (RRID:CVCL_VQ57) | ||||||||||||||||||||||||||||||||
Comments | Population: Caucasian. Characteristics: Can efficiently be convert into cells exhibiting increased adherent, phagocytic and quiescent properties with a transcriptome resembling normal macrophages. Characteristics: Transduced with the retrovirus vector C/EBPaER-GFP which consist of CEBPA fused with the estrogen receptor hormone binding domain and GFP. Genetic integration: Method=Transduction; Gene=HGNC; 1833; CEBPA. Genetic integration: Method=Transduction; Gene=HGNC; 3467; ESR1 (Note=Ligand-binding domain). Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Caution: Was originally (PubMed=23545498) described as originating from the Seraphina cell line (Cellosaurus=CVCL_M646) but was later (PubMed=28494875) shown to derive from RCH-ACV. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. | ||||||||||||||||||||||||||||||||
Sequence variations | |||||||||||||||||||||||||||||||||
Disease | Childhood B acute lymphoblastic leukemia (NCIt: C9140) B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347) B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_1851 (RCH-ACV) | ||||||||||||||||||||||||||||||||
Sex of cell | Female | ||||||||||||||||||||||||||||||||
Age at sampling | 8Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): Millipore=SCC165 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Publications | PubMed=23545498; DOI=10.1016/j.celrep.2013.03.003 PubMed=28494875; DOI=10.1016/j.celrep.2017.04.072 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections (Providers) | Millipore; SCC165 | ||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q93427919 | ||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0030018 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 13-Nov-2018 | ||||||||||||||||||||||||||||||||
Last entry update | 10-Sep-2024 | ||||||||||||||||||||||||||||||||
Version number | 13 |