Cellosaurus cell line VOA4698 (CVCL

Cellosaurus VOA4698 (CVCL_VQ43)

[Text version]

Cell line name

VOA4698

Synonyms

VOA-4698

Accession

CVCL_VQ43

Resource Identification Initiative

To cite this cell line use: VOA4698 (RRID:CVCL_VQ43)

Comments

Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; HGNC:6342; KIT; Simple; p.Met541Leu (c.1621A>C); ClinVar=VCV000041599; Zygosity=Heterozygous (PubMed=27822414).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Ile391Met (c.1173A>G); ClinVar=VCV000135038; Zygosity=Heterozygous (PubMed=27822414).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Cys (c.701A>G); ClinVar=VCV000127820; Zygosity=Heterozygous (PubMed=27822414).

Disease

Low grade ovarian serous adenocarcinoma (NCIt: C105556)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_VQ38 ! VOA4627
CVCL_VQ51 ! VOA4881
CVCL_VQ39 ! VOA5646

Sex of cell

Female

Age at sampling

42Y

Category

Cancer cell line

STR profile

Source(s): PubMed=27822414

Markers:

Amelogenin	X
CSF1PO	11,13
D5S818	13
D7S820	11
D13S317	11,12
D16S539	8,10
D21S11	30
TH01	6
TPOX	12
vWA	15,17

Publications

DOI=10.14288/1.0319145
Dawson A.
Targeted therapy in low-grade serous ovarian carcinoma: characterization of MEK inhibitor response in novel patient-derived cell lines.
Thesis PhD (2016); University of British Columbia; Vancouver; Canada

PubMed=27822414; PMCID=PMC5088288
Fernandez M.L., DiMattia G.E., Dawson A., Bamford S., Anderson S., Hennessy B.T., Anglesio M.S., Shepherd T.G., Salamanca C.M., Hoenisch J., Tinker A., Huntsman D.G., Carey M.S.
Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines.
Am. J. Cancer Res. 6:2235-2251(2016)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_VQ43

Encyclopedic resources

Wikidata; Q98134554

Entry history

Entry creation

07-Sep-2018

Last entry update

19-Dec-2024

Version number