Cellosaurus cell line VOA3448 (CVCL

Cellosaurus VOA3448 (CVCL_VQ40)

[Text version]

Cell line name

VOA3448

Synonyms

VOA-3448

Accession

CVCL_VQ40

Resource Identification Initiative

To cite this cell line use: VOA3448 (RRID:CVCL_VQ40)

Sequence variations

Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Heterozygous (PubMed=27822414).
Mutation; HGNC; HGNC:7029; MET; Simple; p.Asn375Ser (c.1124A>G); ClinVar=VCV000041611; Zygosity=Heterozygous (PubMed=27822414).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Ile391Met (c.1173A>G); ClinVar=VCV000135038; Zygosity=Heterozygous (PubMed=27822414).

Disease

Low grade ovarian serous adenocarcinoma (NCIt: C105556)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_VQ41 ! VOA3723

Sex of cell

Female

Age at sampling

42Y

Category

Cancer cell line

STR profile

Source(s): PubMed=27822414

Markers:

Amelogenin	X
CSF1PO	9,14
D5S818	10,11
D7S820	12
D13S317	9,10
D16S539	10,13
D21S11	28,29
TH01	9,9.3
TPOX	8,11
vWA	16,17

Publications

DOI=10.14288/1.0319145
Dawson A.
Targeted therapy in low-grade serous ovarian carcinoma: characterization of MEK inhibitor response in novel patient-derived cell lines.
Thesis PhD (2016); University of British Columbia; Vancouver; Canada

PubMed=27822414; PMCID=PMC5088288
Fernandez M.L., DiMattia G.E., Dawson A., Bamford S., Anderson S., Hennessy B.T., Anglesio M.S., Shepherd T.G., Salamanca C.M., Hoenisch J., Tinker A., Huntsman D.G., Carey M.S.
Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines.
Am. J. Cancer Res. 6:2235-2251(2016)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_VQ40

Encyclopedic resources

Wikidata; Q98134544

Entry history

Entry creation

07-Sep-2018

Last entry update

19-Dec-2024

Version number