ID   PES 41
AC   CVCL_VP91
SY   PES-41; PES41; PE-MEL-41; PE-Mel-41
DR   cancercelllines; CVCL_VP91
DR   Wikidata; Q98128547
RX   PubMed=16638848;
RX   PubMed=21424129;
RX   PubMed=21863025;
RX   PubMed=29492214;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=29492214).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A); ClinVar=VCV000376303; Zygosity=Unspecified (PubMed=29492214).
CC   Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_VP92 ! PES 43
OI   CVCL_VP93 ! PES 47
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 19-12-24; Version: 10
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RX   PubMed=16638848; DOI=10.1158/1078-0432.CCR-05-1940;
RA   Scala S., Giuliano P., Ascierto P.A., Ierano C., Franco R.,
RA   Napolitano M., Ottaiano A., Lombardi M.L., Luongo M., Simeone E.,
RA   Castiglia D., Mauro F., De Michele I., Calemma R., Botti G.,
RA   Caraco C., Nicoletti G., Satriano R.A., Castello G.;
RT   "Human melanoma metastases express functional CXCR4.";
RL   Clin. Cancer Res. 12:2427-2433(2006).
//
RX   PubMed=21424129; DOI=10.3892/or.2011.1220;
RA   Manca A., Sini M.C., Izzo F., Ascierto P.A., Tatangelo F., Botti G.,
RA   Gentilcore G., Capone M., Mozzillo N., Rozzo C., Cossu A., Tanda F.,
RA   Palmieri G.;
RT   "Induction of arginosuccinate synthetase (ASS) expression affects the
RT   antiproliferative activity of arginine deiminase (ADI) in melanoma
RT   cells.";
RL   Oncol. Rep. 25:1495-1502(2011).
//
RX   PubMed=21863025; DOI=10.1038/bjc.2011.324; PMCID=PMC3185940;
RA   De Luca A., Lamura L., Strizzi L., Roma C., D'Antonio A.,
RA   Margaryan N.V., Pirozzi G., Hsu M.-Y., Botti G., Mari E., Hendrix M.J.C.,
RA   Salomon D.S., Normanno N.;
RT   "Expression and functional role of CRIPTO-1 in cutaneous melanoma.";
RL   Br. J. Cancer 105:1030-1038(2011).
//
RX   PubMed=29492214; DOI=10.18632/oncotarget.23989; PMCID=PMC5823576;
RA   Sini M.C., Doneddu V., Paliogiannis P., Casula M., Colombino M.,
RA   Manca A., Botti G., Ascierto P.A., Lissia A., Cossu A., Palmieri G.;
RT   "Genetic alterations in main candidate genes during melanoma
RT   progression.";
RL   Oncotarget 9:8531-8541(2018).
//