Cell line name |
HCT 116 BRCA2(-/-) clone 46 |
Synonyms |
HCT 116 BRCA2 -/- [46]; HCT 116 BRCA2-/- |
Accession |
CVCL_VP26 |
Resource Identification Initiative |
To cite this cell line use: HCT 116 BRCA2(-/-) clone 46 (RRID:CVCL_VP26) |
Comments |
Population: Caucasian. Knockout cell: Method=Homologous recombination; HGNC; HGNC:1101; BRCA2. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0291 (HCT 116) |
Sex of cell |
Male |
Age at sampling |
48Y |
Category |
Cancer cell line |
STR profile |
Source(s): ECACC=18061301
Markers:Amelogenin | X,Y |
CSF1PO | 7,10 |
D3S1358 | 12,19 |
D5S818 | 10,11 |
D7S820 | 11,12 |
D8S1179 | 12,13,14 |
D13S317 | 10,13 |
D16S539 | 11,13 |
D18S51 | 16,17 |
D21S11 | 29,30 |
FGA | 18,23 |
Penta D | 9,13 |
Penta E | 13,14 |
TH01 | 8,9 |
TPOX | 8 |
vWA | 17,21 |
Run an STR similarity search on this cell line |
Publications | PubMed=25043256; DOI=10.1002/path.4404; PMCID=PMC4882165 Xu H., Xian J., Vire E., McKinney S., Wei V., Wong J., Tong R., Kouzarides T., Caldas C., Aparicio S. Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. J. Pathol. 234:386-397(2014) |
Cross-references |
Cell line collections (Providers) |
CancerTools; 153531
ECACC; 18061301 - Discontinued
Ximbio; 153531
|
Cell line databases/resources |
cancercelllines; CVCL_VP26
|
Encyclopedic resources |
Wikidata; Q93984751
|
Entry history |
Entry creation | 07-Sep-2018 |
Last entry update | 19-Dec-2024 |
Version number | 13 |
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