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Cellosaurus LM-Y1 (CVCL_VN50)

[Text version]
Cell line name LM-Y1
Synonyms LMY1
Accession CVCL_VN50
Resource Identification Initiative To cite this cell line use: LM-Y1 (RRID:CVCL_VN50)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Asn1171del (c.3512_3514delATT); Zygosity=Heterozygous (CelloPub=CLPUB00592).
  • Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Arg1252Pro (c.3755G>C); Zygosity=Heterozygous (CelloPub=CLPUB00592).
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x
Hasegawa H., Yamada Y., Harasawa H., Tsuji T., Murata K., Sugahara K., Tsuruda K., Ikeda S., Imaizumi Y., Tomonaga M., Masuda M., Takasu N., Kamihira S.
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Br. J. Haematol. 128:253-265(2005)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K., Hasegawa H., Yamada Y.
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19710698; DOI=10.1038/leu.2009.171
Hasegawa H., Yamada Y., Iha H., Tsukasaki K., Nagai K., Atogami S., Sugahara K., Tsuruda K., Ishizaki A., Kamihira S.
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Leukemia 23:2090-2101(2009)

PubMed=27193821; DOI=10.1111/cas.12971; PMCID=PMC4982578
Hasegawa H., Bissonnette R.P., Gillings M., Sasaki D., Taniguchi H., Kitanosono H., Tsuruda K., Kosai K., Uno N., Morinaga Y., Imaizumi Y., Miyazaki Y., Yanagihara K.
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.
Cancer Sci. 107:1124-1133(2016)

CLPUB00592
Patel V.M.
Functional interrogations of phospholipase c gamma 1 (PLCG1) mutations in Sezary syndrome.
Thesis PhD (2019); King's College London; London; United Kingdom

Cross-references
Encyclopedic resources Wikidata; Q95982579
Polymorphism and mutation databases IARC_TP53; 27000
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number9