Cellosaurus cell line CUTC61 (CVCL

Cellosaurus CUTC61 (CVCL_VM62)

[Text version]

Cell line name

CUTC61

Accession

CVCL_VM62

Resource Identification Initiative

To cite this cell line use: CUTC61 (RRID:CVCL_VM62)

Comments

Doubling time: 29 hours (PubMed=30733375).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000160364; Zygosity=Heterozygous (PubMed=30733375; PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30733375; PubMed=30737244).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.375+1G>A; ClinVar=VCV000634702; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=30733375; PubMed=30737244).

Disease

Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

72Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30733375; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	10,11
D3S1358	14,15
D5S818	10,12
D7S820	8,10
D8S1179	12,15
D13S317	11,12
D16S539	11,13
D18S51	14,19
D21S11	28,30
FGA	24,25
TH01	8,9
TPOX	8
vWA	17,18

Publications

PubMed=30733375; DOI=10.1158/1541-7786.MCR-18-1026; PMCID=PMC6711777
Schweppe R.E., Pozdeyev N., Pike L.A., Korch C.T., Zhou Q., Sams S.B., Sharma V., Pugazhenthi U., Raeburn C.D., Albuja-Cruz M.B., Reigan P., LaBarbera D.V., Landa-Lopez I., Knauf J.A., Fagin J.A., Haugen B.R.
Establishment and characterization of four novel thyroid cancer cell lines and PDX models expressing the RET/PTC1 rearrangement, BRAFV600E, or RASQ61R as drivers.
Mol. Cancer Res. 17:1036-1048(2019)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_VM62

Encyclopedic resources

Wikidata; Q93460554

Entry history

Entry creation

25-Feb-2019

Last entry update

19-Dec-2024

Version number