ID   HL-60 blast
AC   CVCL_VK43
SY   HL-60 Blast; HL-60_blast; HL60 blast
DR   cancercelllines; CVCL_VK43
DR   Cosmic; 850383
DR   Wikidata; Q94211458
RX   PubMed=6945469;
RX   PubMed=10966170;
CC   Population: Caucasian.
CC   Characteristics: Subclone of HL-60 resistant to the growth and differentiation effects of various compounds.
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (PubMed=10966170).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 05-10-23; Version: 12
//
RX   PubMed=6945469; DOI=10.1016/0145-2126(81)90018-7;
RA   Major P.P., Griffin J.D., Minden M.D., Kufe D.W.;
RT   "A blast subclone of the HL-60 human promyelocytic cell line.";
RL   Leuk. Res. 5:429-430(1981).
//
RX   PubMed=10966170; DOI=10.1034/j.1600-0609.2000.90181.x;
RA   Aggerholm A., Gronbaek K., Guldberg P., Hokland P.;
RT   "Mutational analysis of the tumour suppressor gene MMAC1/PTEN in
RT   malignant myeloid disorders.";
RL   Eur. J. Haematol. 65:109-113(2000).
//