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Cellosaurus ORL-188 (CVCL_VJ42)

[Text version]
Cell line name ORL-188
Synonyms ORL-188T; 188T
Accession CVCL_VJ42
Resource Identification Initiative To cite this cell line use: ORL-188 (RRID:CVCL_VJ42)
Comments Population: Malaysian.
Omics: CRISPR phenotypic screen.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Heterozygous (PubMed=27050151).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204_Tyr205del (c.609_614del); Zygosity=Unspecified (PubMed=27050151).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): PubMed=27050151

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133819
D3S135816
D5S81810,13
D7S82010,11
D8S117913,16
D13S3178,11
D16S53910
D18S5117,19
D19S43314,14.2
D21S1131
FGA24.2,27
TH017,8
TPOX9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115
Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A., Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:E80229-E80229(2013)

PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689
Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P., Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G., Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A., Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H., Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C., McDermott U., Garnett M.J., Cheong S.-C.
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM02000
CRISP screens repositories BioGRID_ORCS_Cell_line; 1276
Encyclopedic resources Wikidata; Q98128362
Polymorphism and mutation databases Cosmic; 2531655
Cosmic; 2559742
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number11