ID   ORL-174
AC   CVCL_VJ41
SY   ORL-174T; 174T
DR   BioGRID_ORCS_Cell_line; 1275
DR   Cell_Model_Passport; SIDM02001
DR   Cosmic; 2531642
DR   Cosmic; 2559741
DR   Wikidata; Q98128361
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Indian.
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Thr3033Asnfs*11 (c.9097dupA); ClinVar=VCV000038208; Zygosity=Unspecified (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu88Ter (c.262G>T); ClinVar=VCV000376305; Zygosity=Heterozygous (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27050151).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12,13
ST   D16S539: 9,11
ST   D18S51: 12,19
ST   D19S433: 14
ST   D21S11: 28,29
ST   D2S1338: 20
ST   D3S1358: 16
ST   D5S818: 9
ST   D7S820: 8,10
ST   D8S1179: 11,14
ST   FGA: 24,25
ST   TH01: 8
ST   TPOX: 8,9
ST   vWA: 14,18
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 19-12-24; Version: 12
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:E80229-E80229(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//