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Cellosaurus ORL-153 (CVCL_VJ38)

[Text version]
Cell line name ORL-153
Synonyms ORL-153T; 153T
Accession CVCL_VJ38
Resource Identification Initiative To cite this cell line use: ORL-153 (RRID:CVCL_VJ38)
Comments Population: Indian.
Omics: CRISPR phenotypic screen.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (PubMed=27050151).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Tyr997Ter (c.2991T>G); Zygosity=Unspecified (PubMed=27050151).
Disease Gingival squamous cell carcinoma (NCIt: C129857)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): PubMed=27050151

Markers:
AmelogeninX,Y
CSF1PO10
D2S133819,23
D3S135816,17
D5S81811,12
D7S8207,12
D8S117910,17
D13S31710,14
D16S53912
D18S5113,14
D19S43314,16
D21S1128,31
FGA21
TH019,9.3
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115
Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A., Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:E80229-E80229(2013)

PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689
Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P., Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G., Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A., Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H., Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C., McDermott U., Garnett M.J., Cheong S.-C.
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ38
Cell_Model_Passport; SIDM02004
CRISP screens repositories BioGRID_ORCS_Cell_line; 1274
Encyclopedic resources Wikidata; Q98128357
Polymorphism and mutation databases Cosmic; 2531651
Cosmic; 2559738
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number11