Cellosaurus cell line BCWM.1/IR (CVCL

Cellosaurus BCWM.1/IR (CVCL_VJ30)

Cross-references
Cell line name	BCWM.1/IR
Synonyms	BCWM_1/IR; BC/IR
Accession	CVCL_VJ30
Resource Identification Initiative	To cite this cell line use: BCWM.1/IR (RRID:CVCL_VJ30)
Comments	Selected for resistance to: ChEBI; CHEBI_76612; Ibrutinib (Imbruvica). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (from parent cell line).
Disease	Waldenstrom macroglobulinemia (NCIt: C80307) Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A035 (BCWM.1)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=25382610; DOI=10.1038/bcj.2014.74; PMCID=PMC5424099 Chitta K.S., Paulus A., Caulfield T.R., Akhtar S., Blake M.K.K., Ailawadhi S., Knight J., Heckman M.G., Pinkerton A.B., Chanan-Khan A.A. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia. Blood Cancer J. 4:e260.1-e260.10(2014) PubMed=28548645; DOI=10.1038/bcj.2017.40; PMCID=PMC5518884 Paulus A., Akhtar S., Yousaf H.M., Manna A., Paulus S.M., Bashir Y., Caulfield T.R., Blake M.K.K., Chitta K.S., Wang X., Asmann Y., Hudec R., Springer W., Ailawadhi S., Chanan-Khan A.A. Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment. Blood Cancer J. 7:e565.1-e565.11(2017)
Cell line databases/resources	cancercelllines; CVCL_VJ30
Encyclopedic resources	Wikidata; Q93424848
Polymorphism and mutation databases	Cosmic; 2645643
Entry history
Entry creation	07-Sep-2018
Last entry update	19-Dec-2024
Version number	8