ID   HiDEP-1
AC   CVCL_VI03
SY   Human iPS cell-Derived Erythroid Progenitor-1
DR   RCB; RCB4554
DR   Wikidata; Q54889536
RX   Patent=US8975072;
RX   PubMed=23533656;
CC   Population: Japanese.
CC   Characteristics: After in vitro induction of differentiation, will produce enucleated red blood cells. Expresses embryonic and fetal hemoglobin.
CC   Characteristics: Expression of the HPV16 E6 and E7 genes is induced by tetracycline (PubMed=23533656).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11556; TAL1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Cell type: Erythroid progenitor cell; CL=CL_0000038.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VI02 ! HiPS-RIKEN-4A-TAL1
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 14-05-18; Last updated: 19-12-24; Version: 13
//
RX   Patent=US8975072;
RA   Nakamura Y., Kurita R.;
RT   "Human erythroid progenitor cell line comprising HPV E6/E7 operably
RT   linked to an inducible promoter and method for producing human
RT   enucleated red blood cells.";
RL   Patent number US8975072, 10-Mar-2015.
//
RX   PubMed=23533656; DOI=10.1371/journal.pone.0059890; PMCID=PMC3606290;
RA   Kurita R., Suda N., Sudo K., Miharada K., Hiroyama T., Miyoshi H.,
RA   Tani K., Nakamura Y.;
RT   "Establishment of immortalized human erythroid progenitor cell lines
RT   able to produce enucleated red blood cells.";
RL   PLoS ONE 8:E59890-E59890(2013).
//