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Cellosaurus HME348 cdk4 (CVCL_VG06)

[Text version]
Cell line name HME348 cdk4
Synonyms HME348cdk4; 348hTERT
Accession CVCL_VG06
Resource Identification Initiative To cite this cell line use: HME348 cdk4 (RRID:CVCL_VG06)
Comments Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Tyr2215Serfs*13 (c.6644_6647delACTC) (6872del4); ClinVar=VCV000038060; Zygosity=Heterozygous (PubMed=16541310).
Disease BRCA2-associated hereditary breast and ovarian cancer syndrome (NCIt: C36101)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VG05 (HME348)
Children:
CVCL_VG08 (HME348 cdk4/hTERT)
Sex of cell Female
Age at sampling 44Y
Category Finite cell line
Publications

PubMed=16541310; DOI=10.1007/s10549-006-9189-9
Lewis C.M., Herbert B.-S., Bu D.-W., Halloway S., Beck A., Shadeo A., Zhang C., Ashfaq R., Shay J.W., Euhus D.M.
Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier.
Breast Cancer Res. Treat. 99:103-115(2006)

Cross-references
Encyclopedic resources Wikidata; Q54889916
Entry history
Entry creation14-May-2018
Last entry update19-Dec-2024
Version number11